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Chinese medicine yields secrets: Atomic mechanism of two-headed molecule derived from Chang Shan, a traditional chinese herb

The mysterious inner workings of Chang Shan — a Chinese herbal medicine used for thousands of years to treat fevers associated with malaria — have been uncovered thanks to a high-resolution structure solved by scientists.

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Nutrient-sensing enzymes key to starvation response and survival in newborn mammals

In the perilous hours immediately after birth, a newborn mammal must survive the sudden loss of food supply from its mother. Under normal circumstances, newborns mount a metabolic response to ward off starvation until feeding occurs. This survival response involves a process of controlled breakdown of internal energetic sources known as autophagy. Although autophagy has been well documented, the key mechanistic regulators of autophagy in vivo have remained poorly understood. Researchers have now discovered that a family of nutrient-sensing enzymes, dubbed Rag GTPases, modulates the activity of the mTORC1 protein complex, whose inhibition is essential for autophagy and survival in newborns.

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Genetic clues to insulin production: Genomic analysis method helps track genetic contributors relevant to diabetes

A cutting-edge genomic analysis method has helped researchers track new genetic contributors relevant to diabetes. The results provide a first example that the new tool can help decipher many complex diseases such as obesity and cancer.

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Excessive protein synthesis linked to autistic-like behaviors, neuroscientists find

Autistic-like behaviors can be partially remedied by normalizing excessive levels of protein synthesis in the brain, a team of researchers has found in a study of laboratory mice. The findings provide a pathway to the creation of pharmaceuticals aimed at treating autism spectrum disorders (ASD) that are associated with diminished social interaction skills, impaired communication ability, and repetitive behaviors.

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Study shows rapid warming on the West Antarctic ice sheet

In a discovery that raises further concerns about the future contribution of Antarctica to sea level rise, a new study finds that the western part of the ice sheet is experiencing nearly twice as much warming as previously thought.

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EU grants for international master’s or doctorate in materials science

Students with a background in science or engineering can apply for a binational AMASE master’s degree including a grant from the European Union.

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Molecular levers may make materials better

In a forced game of molecular tug-of war, some strings of atoms can act like a lever, accelerating reactions 1000 times faster than other molecules. The discovery suggests that scientists could use these molecular levers to drive chemical and mechanical reactivity among atoms and ultimately engineer more efficient materials.

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Boosting galactan sugars could boost biofuel production

Researchers have identified the first enzyme capable of substantially boosting the amount of galactan sugars in plant cell walls. Readily fermented, galactan sugars are a target of interest for researchers in advanced biofuels produced from cellulosic biomass.

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Multinozzle Emitter Array Chips for Small-Volume Proteomics

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Analytical Chemistry
DOI: 10.1021/ac3032965

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A General Way to Assay Protein by Coupling Peptide with Signal Reporter via Supermolecule Formation

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Analytical Chemistry
DOI: 10.1021/ac302906c

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